Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
نویسندگان
چکیده
منابع مشابه
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus.
We report the crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus, a major human pathogen, to 2.8-A resolution. This enzyme is a key target for developing specific antiviral therapy. The structure of the catalytic domain contains 531 residues folded in the characteristic fingers, palm, and thumb subdomains. The fingers subdomain contains a region, the "fingertips," that s...
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ژورنال
عنوان ژورنال: Structure
سال: 1999
ISSN: 0969-2126
DOI: 10.1016/s0969-2126(00)80031-3